Sir Keir Starmer has ruled out there being a Scottish independence referendum while he is prime minister.
The Labour leader told the BBC he would build a "stronger Scotland in a stronger United Kingdom" and that another independence referendum was not a priority.
His comments come after first minister John Swinney spoke of his desire to achieve "demonstrable support" for independence.
Veteran politician Michael Gove - who now has the title Lord Gove of Torry - also recently admitted the UK government may be forced to backtrack on a second independence vote, if there was shown to be "overwhelming support".
But visiting Scotland ahead of Thursday's Hamilton, Larkhall and Stonehouse by-election, Starmer said: "Nobody's raising that with me as their first priority."
Speaking in an interview to be broadcast on the BBC's Good Morning Scotland programme later, Starmer said an SNP victory at next year's Holyrood elections would do nothing to change his stance.
He said, the BBC reports: "I think it's really important to focus on the priorities that matter most.
"We got a big election win last year on the basis that we would stabilise the economy and ensure that on that foundation we built a stronger Scotland in a stronger United Kingdom and that's what I intend to do.
"Nobody's raising that with me as their first priority, certainly in the discussions I'm having with the first minister.
"We're talking about jobs, energy, security and dealing with the cost of living crisis."