New research shows that working from home can increase the risk of illnesses like depression, dementia and heart disease.
MindGym, the behavioural change consultancy, and non-profit the Longevity Forum, warn that uninterrupted remote working can erode energy levels and alter the way the brain works.
This increases the chances of mental or physical illness.
Octavius Black, Chief Executive of MindGym, said: "We know that people who have disparate connections with more diverse people are physically and mentally healthier than those that are not.
"Your best chance of getting that is in the office through what we call casual collisions where you happen to bump into someone or sit down with someone or overhear a conversation."
The report, which consulted 62% of FTSE100 companies and 59% of the S&P, also shows that remote workers miss out on conversing with workers outside of their circle of eight to 10 people.
"It’s really important for people’s health generally to be coming back into work, not every day all the time, but a significant enough amount to build those relationships,” added Mr Black.
"The people who most want to stay at home tend to be those with children who are quite advanced in their career because they think ‘I want to be with my family and I kind of know it all already’.
"The younger generations first of all find that the workplace is a source of friendship and connection but also a great opportunity to learn."